OXIDATION OF OCTADECAPENTAENOIC (18 5N-3) ACID WITH SOYBEAN 15-LYPOXYGENASE

Authors
KUKLEV DV KOGTEVA GS LATYSHEV NA BEZUGLOV VV
Citation
Dv. Kuklev et al., OXIDATION OF OCTADECAPENTAENOIC (18 5N-3) ACID WITH SOYBEAN 15-LYPOXYGENASE, Bioorganiceskaa himia, 21(8), 1995, pp. 651-653
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
21
Issue
8
Year of publication
1995
Pages
651 - 653
Database
ISI
SICI code
0132-3423(1995)21:8<651:OOO(5A>2.0.ZU;2-C
Abstract
It is shown for the first time that (3Z,6Z,9Z,12Z,15Z)-octadecapentaen oic acid (ODPA) is readily oxidized with soybean 15-lypoxygenase to fo rm new oxylipins, Based on NMR, UV, and mass-spectrometry, the primary peroxidation product was identified as 3Z,6Z,9Z,11E,15Z)-13-hydropero xyoctadecapentaenoic acid, and two secondary products were identified as (13S,3Z,6Z,9Z,11E,15Z)- 13-hydroxyoctadecapentaenoic and (3Z,6Z,9Z, 11E)-13-oxotridecatetraenoic acids. The lipoxygenase oxidation product s were found to contain no 9-regioisomers and ketodienes.