ANTIFUNGAL ACTIVITY OF HALOPHENOLS AND HALONITROPHENOLS

Thirty one compounds (phenol; its 12 possible monohalo analogues; 18 n itrophenols (2- and 4-nitrophenols, 4-, 5-, and 6-halo-2-nitrophenols, 3-halo-4-nitrophenols)) were tested for antifungal activity against s ix fungi (A. niger, A. oryzae, M. verrucaria, T. viride, M. cirinelloi des, and T. mentayrophytes) in Sabouraud dextrose broth. The two most fungitoxic compounds of those studied were 5-fluoro- and 5-iodo-2-nitr ophenols which inhibited all the fungi at concentrations under 10 mu g /ml. 6-Iodo-2-nitrophenol inhibited five fungi at a concentration belo w 10 mu g/ml and M. cirinelloides at 10-100 mu g/ml.