LYMPHOCYTE-PROLIFERATION ASSAY, A POSSIBL E ALTERNATIVE WAY OF DEMONSTRATING ALLERGIC CONTACT-DERMATITIS IN RESPONSE TO CHLOROACETOPHENONE

Authors
BRAND CU SCHMIDLI J BALLMERWEBER B HUNZIKER T
Citation
Cu. Brand et al., LYMPHOCYTE-PROLIFERATION ASSAY, A POSSIBL E ALTERNATIVE WAY OF DEMONSTRATING ALLERGIC CONTACT-DERMATITIS IN RESPONSE TO CHLOROACETOPHENONE, Hautarzt, 46(10), 1995, pp. 702-704
Citations number
6
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Hautarzt → ACNP
ISSN journal
00178470
Volume
46
Issue
10
Year of publication
1995
Pages
702 - 704
Database
ISI
SICI code
0017-8470(1995)46:10<702:LAAPEA>2.0.ZU;2-T
Abstract
We report on a case of pronounced sensitization to chloroacetophenone tear gas that developed after repeated occupational skin exposure in a 57-year-old police officer. Mainly in the presence of moisture and oc clusion, cutaneous application of chloroacetophenone leads to severe i rritant, and often also allergic, skin reactions. In patch testing the demonstration of allergic contact dermatitis in response to chloroace tophenone is hampered by the irritative potential of this substance ev en at low concentrations. This diagnostic bias can be overcome by the lymphocyte proliferation assay.