Ll. Hsieh et Yc. Huang, LOSS OF HETEROZYGOSITY OF APC MCC GENE IN DIFFERENTIATED AND UNDIFFERENTIATED GASTRIC CARCINOMAS IN TAIWAN/, Cancer letters, 96(2), 1995, pp. 169-174
Recently, two genes in 5q21 involved in colon carcinogenesis, APC and
MCC, were identified, and also shown to be associated with the develop
ment of esophageal and lung cancers. To determine if these genes are a
lso involved in the development of gastric cancer, 79 primary human ga
stric cancers were examined for loss of heterozygosity of APC or MCC o
r both. Loss of APC was detected in 20% of 15 informative differentiat
ed cases, but not in 20 informative undifferentiated cases, while loss
of MCC occurred in 23.5% of 17 informative undifferentiated cases, bu
t not in 19 informative differentiated cases, These data suggest that
loss of heterozygosity of APC/MCC gene is involved in the development
of gastric carcinomas, and that distinctly different molecular mechani
sm(s) may be responsible for the development of differentiated and und
ifferentiated gastric carcinomas.