INFLUENCE OF VARIOUS CONCENTRATIONS OF TAXOL ON CELL-SURVIVAL, MICRONUCLEI INDUCTION, AND LDH ACTIVITY IN CULTURED V79 CELLS

Authors
JAGETIA GC ADIGA SK
Citation
Gc. Jagetia et Sk. Adiga, INFLUENCE OF VARIOUS CONCENTRATIONS OF TAXOL ON CELL-SURVIVAL, MICRONUCLEI INDUCTION, AND LDH ACTIVITY IN CULTURED V79 CELLS, Cancer letters, 96(2), 1995, pp. 195-200
Citations number
30
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
96
Issue
2
Year of publication
1995
Pages
195 - 200
Database
ISI
SICI code
0304-3835(1995)96:2<195:IOVCOT>2.0.ZU;2-W
Abstract
The clastogenic effect of various concentrations of taxol, namely 0, 1 0, 25, 50, 100, 250 and 500 nM was evaluated in V79 cells grown in vit ro. Treatment of V79 cells with different concentrations of taxol redu ced the survival in a concentration dependent manner. However, the fre quency of micronuclei increased in a concentration dependent manner an d the dose response was linear quadratic. Similarly, lactate dehydroge nase also increased with the increase in taxol concentration. The micr onuclei and lactate dehydrogenase showed an inverse relationship with the cell survival.