INCREASING DEVELOPMENT OF PEPSINOGEN-ALTERED PYLORIC GLANDS AND ADENOCARCINOMA IN GLANDULAR STOMACH OF ANALBUMINEMIC RATS

The susceptibility of pepsinogen-altered pyloric glands (PAPG) and neo plastic glandular stomach lesions induced by N-methyl-N'-nitro-N-nitro soguanidine (MNNG) and catechol or sodium cholate in Nagase analbumine mic rats (NAR) was compared to Sprague-Dawley rats (SD). Male NAR and SD rats were given a single dose of 80 mg/kg body weight of MNNG by ga stric intubation and, 2 weeks later, fed basal diet containing 0.8% ca techol or 0.3% sodium cholate for 18 weeks, The animals were killed at the end of week 20 or after maintenance on basal diet at week 60. The number of pepsinogen-altered pyloric glands at week 20 was significan tly (P < 0.001) higher in NAR fed either catechol or sodium cholate co mpared with SD rats. At week 60, adenomatous hyperplasias and adenocar cinomas were observed in 7 (88%; P < 0.01) and 3 (38%; P < 0.01) of 8 NAR fed catechol and in 4 (22%) and 0 of 18 SD rats, respectively. The results show that the frequency of PAPG in NAR and SD rats is related to the susceptibility to glandular stomach carcinoma. PAPG is a usefu l endpoint lesion for evaluation of gastric carcinogenicity in a 20-we ek carcinogenicity test, and NAR are sensitive for glandular stomach c arcinogenesis.