RADIOIMMUNOANALYSIS OF ANTIBODIES OBTAINED BY A LIPOSOMAL ADJUVANT

An experimental model for preparing and testing by the radioimmunoanal ysis (RIA) method the immunoadjuvant capacity of the dehydration-rehyd ration vesicles (DRV) over the Freund complete adjuvant (FCA) is prese nted. The humoral antibody;response to bovine serum albumin (BSA), hum an transferrin and human alpha-foetoprotein was investigated on rats. The concentration of specific antibodies (a) and the average antibody affinity constant (k) are the two intrinsic parameters of the antisera measured by RIA we referred to. The experimental results show that k is higher and a is smaller for the liposomal adjuvant than for the Fre und one.