SOLITARY GIANT XANTHOGRANULOMA AND BENIGN CEPHALIC HISTIOCYTOSIS - VARIANTS OF JUVENILE XANTHOGRANULOMA

Sequential biopsies taken from a patient with a solitary giant xanthog ranuloma, an exaggerated macronodular (>5 cm in diameter) variant of j uvenile xanthogranuloma, and from a patient with benign cephalic histi ocytosis, revealed a characteristic time sequence of histopathological findings. Early stages of the diseases showed a monomorphous infiltra te of mononuclear vacuolated histiocytes positive for KiM1p, HAM56 and -factor XIIIa and were characterized by clusters of comma-shaped bodie s. This was followed by a polymorphous mixture of various mononuclear and multinucleate histiocytes additionally labelling with KP1 (CD68) a nd, in occasional cells, for the adherence of peanut agglutinin, A var iety of ultrastructural changes were found, including dense and regula rly laminated bodies or lipid droplets, Our findings indicate that bot h entities are variants of a xanthogranulomatous reaction.