The usefulness of fine-needle aspiration cytology (FNAC) in the diagno
sis and treatment of submandibular gland lesions is not well known. Th
e 210 FNACs taken from submandibular gland lesions at Turku University
Central Hospital between 1984 and 1991 were reviewed. Of these FNACs,
78 samples from primary lesions were confirmed histologically. Within
this subset 10 FNACs were taken from benign neoplasms, all of which w
ere correctly classified (sensitivity 100 per cent; specificity 88 per
cent). Only four of the 14 FNACs from malignant lesions were cytologi
cally considered malignant (sensitivity 29 per cent). On the other han
d, four FNACs raised a false suspicion of malignancy (specificity 6 pe
r cent). Out of 54 FNACs from non-neoplastic lesions 43 were correct (
sensitivity 80 per cent; specificity 63 per cent). There were 104 pati
ents (123 FNACs), who had not been operated on: the followup of these
patients shows that in this subset of FNACs there were no false malign
ant but probably one false benign finding (1 per cent). We conclude th
at FNAC can offer valuable information about the type of the submandib
ular gland lesion, but the decision of operative and other treatment s
hould not be based solely on the result of FNAC.