ACQUIRED FACTOR VIII-SPECIFIC ANTIBODY DISORDER ACCOMPANIED BY A LIFE-THREATENING RETROPERITONEAL HEMATOMA

A male patient, aged 58, without any discernible underlying disease de veloped a massive hemorrhage in the retroperitoneal cavity and in the femoral muscle, The hemorrhagic tendency of the patient was found to b e due to the acquired anti-Factor VIII specific autoantibody in the bl ood, A concentrate of an activated prothrombin complex (FEIBA: Factor eight inhibitor bypassing activity) was administered and produced a re markable effect in stemning the bleeding tendency of the patient, Immu nosuppressive therapy was also effective for the control of the bleedi ng.