ASYMMETRIC-SYNTHESIS OF 12-EPI-PGF(2-ALPHA) BY A PALLADIUM-MEDIATED, 3-COMPONENT COUPLING REACTION

Authors
LEE NH LAROCK RC
Citation
Nh. Lee et Rc. Larock, ASYMMETRIC-SYNTHESIS OF 12-EPI-PGF(2-ALPHA) BY A PALLADIUM-MEDIATED, 3-COMPONENT COUPLING REACTION, Bulletin of the Korean Chemical Society, 16(9), 1995, pp. 859-863
Citations number
26
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Korean Chemical Society → ACNP
ISSN journal
02532964
Volume
16
Issue
9
Year of publication
1995
Pages
859 - 863
Database
ISI
SICI code
0253-2964(1995)16:9<859:AO1BAP>2.0.ZU;2-1
Abstract
The prostaglandin analogue 12-epi-PGF(2 alpha) (2) has been synthesize d from optically active cis-4-t-butyldimethylsilyloxy-2-cyclopenten-1- ol (4b) in 4 steps in an overall yield of 21%. An extremely efficient Pd(II)-mediated, three-component coupling reaction is employed to obta in the key intermediate 9.