The Alcohol Use Disorders Identification Test (AUDIT) is a 10-item que
stionnaire designed by the World Health Organization to screen for haz
ardous alcohol intake in primary health care settings. In this longitu
dinal study we examine its performance in predicting alcohol-related h
arm over the full range of its scores using receiver operating charact
eristic analyses. Three hundred and thirty ambulatory care patients we
re interviewed using a detailed assessment schedule which included the
AUDIT questions. After 2-3 years, subjects were reviewed and their ex
perience of alcohol-related medical and social harm assessed by interv
iew and perusal of medical records. AUDIT was a good predictor of both
alcohol-related social and medical problems. Cut-off points of 7-8 ma
ximized discrimination in the prediction a trauma and hypertension. Hi
gher cut-offs (12 and 22) provided better discrimination in the predic
tion of alcohol-related social problems and of liver disease or gastro
intestinal bleeding, but high specificity was offset by reduced sensit
ivity. We conclude that the recommended cut-off score of eight is a re
asonable approximation to the optimal for a variety of endpoints.