A COMPARISON OF THE INHIBITORY EFFECT OF CROMOLINE AND NEDOCROMIL NA ON HISTAMINE-RELEASE FROM AIRWAY METACHROMATIC CELLS AND FROM PERIPHERAL BASOPHILS

Authors
KIVITY S ON A AGAMI O LEVO Y FIREMAN E
Citation
S. Kivity et al., A COMPARISON OF THE INHIBITORY EFFECT OF CROMOLINE AND NEDOCROMIL NA ON HISTAMINE-RELEASE FROM AIRWAY METACHROMATIC CELLS AND FROM PERIPHERAL BASOPHILS, Immunology letters, 53(2-3), 1996, pp. 147-151
Citations number
20
Categorie Soggetti
Immunology
Journal title
Immunology letters → ACNP
ISSN journal
01652478
Volume
53
Issue
2-3
Year of publication
1996
Pages
147 - 151
Database
ISI
SICI code
0165-2478(1996)53:2-3<147:ACOTIE>2.0.ZU;2-N
Abstract
Metachromatic cells are increased in the airways of asthmatic patients . We obtained metachromatic cells from asthmatic airways using an indu ced sputum technique. The histamine release following ConA, anti-IgE a nd anti-IgE + IL(3) from those cells were evaluated before and followi ng the addition of cromoline Na and nedocromil Na. Metachromatic cells had a higher rate of spontaneous histamine release when compared to p eripheral basophils. Cromoline Na and nedocromil Na inhibited histamin e release from triggered metachromatic cells but not from peripheral b asophils. It is concluded that airway metachromatic cells from asthmat ics behave differently than peripheral basophils.