THE CHANGING IMMUNOLOGY OF ORGAN-TRANSPLANTATION

Authors
STARZL TE DEMETRIS AJ MURASE N TRUCCO M THOMSON AW RAO AS
Citation
Te. Starzl et al., THE CHANGING IMMUNOLOGY OF ORGAN-TRANSPLANTATION, Hospital practice, 30(10), 1995, pp. 31-42
Citations number
NO
Categorie Soggetti
Medicine, General & Internal
Journal title
Hospital practice → ACNP
ISSN journal
87502836
Volume
30
Issue
10
Year of publication
1995
Pages
31 - 42
Database
ISI
SICI code
8750-2836(1995)30:10<31:TCIOO>2.0.ZU;2-Z
Abstract
The engrafted organ becomes a chimera as the recipient's leukocytes st ation themselves in the transplant, Remarkably, the recipient becomes chimeric as well, in a reverse migration involving immune cells from t he graft. Interactions between donor and recipient cells are tolerogen ic-a process with implications for the goal of graft acceptance with m inimal immunosuppression.