SYNTHESIS OF 5,8-DIMETHOXY-2(1H)-QUINOLINONES BY INTRAMOLECULAR WITTIG REACTION

Authors
FERRER P AVENDANO C SOLLHUBER M
Citation
P. Ferrer et al., SYNTHESIS OF 5,8-DIMETHOXY-2(1H)-QUINOLINONES BY INTRAMOLECULAR WITTIG REACTION, Liebigs Annalen, (10), 1995, pp. 1895-1899
Citations number
24
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen → ACNP
ISSN journal
09473440
Issue
10
Year of publication
1995
Pages
1895 - 1899
Database
ISI
SICI code
0947-3440(1995):10<1895:SO5BIW>2.0.ZU;2-8
Abstract
The title compounds 12, which are key intermediates for antitumoral di azaquinomycin A analogues, are obtained by intramolecular Wittig react ion of lpha-oxoacylamino)phenyl]alkyltriphenylphosphonium salts 11, wh ich are prepared via lithiation of 2',5'-dimethoxy-N-pivaloylaniline 6 . The applicability of this route to polysubstituted 2(1H)-quinolinone s 12 and 17 is examined.