Background: The objective of this study was to evaluate the similariti
es between solitary plasmacytoma of bone (SPB) and extramedullary plas
macytoma (EP). Patients and methods: The clinical features, treatment
and survival of 54 patients with localized plasmacytoma (LP) seen at 4
Italian institutions between May 1968 and February 1990 were carefull
y reviewed. Follow-up was expected to continue until June 1993. Result
s: Thirty-two patients were classified as having SPB and 22 EP. Most o
f the patients were males, particularly those in the SPB group. Their
median age at diagnosis was 54 years and no significant difference bet
ween the two groups was observed. SPB occurred most frequently in the
vertebral column (42%) and EP in the upper respiratory tract (73%). Fi
fteen patients with SPB and 2 with EP had paraproteinemia at diagnosis
, multiple myeloma (MM) became evident in 75% of the patients with per
sistent paraprotein after therapy, and in only 22% of those in whom it
disappeared. Four patients in the SPB group had immunoparesis, and 3
developed MM. Disease progression toward MM was significantly differen
t (p = 0.003) in the two groups, while overall survival differences we
re not significant (p = 0.07) unless unrelated causes were excluded (p
= 0.02). Adjuvant chemotherapy did not seem to limit diffusion of the
disease. Conclusions: Although EP and SPB are both localized forms of
plasma cell dyscrasias, SPB seems to have a greater tendency to progr
ess in MM. II appears, however, that the apparent stronger propensity
of SPB to progress is actually due to the great number of cases that a
t diagnosis conceal an occult MM.