DOSIMETRY AND STANDARDIZATION OF TRITIUM IN RUSSIA

Specific features of metabolism of different classes of tritium compou nds have been studied in experiments with rats and mice. The results i ndicated the value of intracellular content of water is by 15-40% less than the average content of water in the whole tissue, Protracted ret ention in lungs of particles of luminous compounds and Ti tritide inha lated or introduced into trachea was shown. So, the particles are assi gned to class Y according to ICRP. Foreign low-molecular organic triti um compounds are effectively excreted with urine. Biogenic tritium com pounds are bound in tissues at synthesis of biopolymers in dependence on need of body in them. According to our experiments, 1 to 90 % of tr itium is separated from all incorporated compounds into body water in the form of HTO. The obtained metabolic data along with results of new radiobiological experiments on mice for: RBE and biogenic tritium com pounds effectiveness were the basis for development and introduction i n Russia of standards for insoluble and biogenic tritium compounds and separately - for labelled precursors of nucleic acids.