DECREASED LEVELS OF PREPROTACHYKININ-A AND TACHYKININ NK1 RECEPTOR MESSENGER-RNA IN SPECIFIC REGIONS OF THE RAT STRIATUM AFTER ELECTROCONVULSIVE STIMULI

Authors
ZACHRISSON O MATHE AA LINDEFORS N
Citation
O. Zachrisson et al., DECREASED LEVELS OF PREPROTACHYKININ-A AND TACHYKININ NK1 RECEPTOR MESSENGER-RNA IN SPECIFIC REGIONS OF THE RAT STRIATUM AFTER ELECTROCONVULSIVE STIMULI, European journal of pharmacology, 319(2-3), 1997, pp. 191-195
Citations number
28
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
319
Issue
2-3
Year of publication
1997
Pages
191 - 195
Database
ISI
SICI code
0014-2999(1997)319:2-3<191:DLOPAT>2.0.ZU;2-1
Abstract
The effects of electroconvulsive stimuli on the expression of mRNAs co ding for preprotachykinin-A and the substance P-sensitive tachykinin N K1 receptor were examined in subregions of the rat striatum. In the el ectroconvulsive stimuli-treated animals, a 43% decrease in preprotachy kinin-A mRNA was detected in the dorso-lateral caudate-putamen as comp ared to sham electroconvulsive stimuli treated animals. A 75% decrease in numerical density of tachykinin NK1 receptor mRNA positive neurons was found in the caudal part of the nucleus accumbens core. These fin dings provide new evidence for selective effects of electroconvulsive stimuli on specific populations of neurons in the rat striatum.