ANTIISCHEMIC CARDIOPROTECTIVE EFFECT OF M EXIDOL

Antiischemic cardioprotective effects of a new 3-hydroxypyridine antio xidant mexidol were investigated after experimental coronary artery oc clusion in rats and dogs. influence of the drug on myocardial infarct size was estimated in rats by ratio of necrotic to ischemic zone size in 4 hours after ligation of anterior descending coronary artery. Acti on of mexidol on collateral coronary blood flow, dp/dt(max), and some parameters of energy metabolism of ischemic myocardium was studied in dogs. Necrotic to ischemic zone ratio was lower in mexidol treated (30 mg/kg) than in control animals (46+/-5,6% and 68+/-4,3%, respectively ). Compared to control group, intravenous administration of 5 and 20 m g/kg of mexidol significantly increased collateral coronary blood flow and dp/dt(max), decreased excess lactate in the blood drained from th e ischemic zone and inhibited glucose consumption by ischemic myocardi um.