CHELATE SYNTHESIS OF ETHOXYCARBONYL-4-HYDROXY-2-TRIFLUOROMETHYLPYRIDINE FROM ETHYL ACETOACETATE AND TRIFLUOROACETONITRILE

Authors
DOROKHOV VA VASILEV LS SURZHIKOV FE BOGDANOV VS
Citation
Va. Dorokhov et al., CHELATE SYNTHESIS OF ETHOXYCARBONYL-4-HYDROXY-2-TRIFLUOROMETHYLPYRIDINE FROM ETHYL ACETOACETATE AND TRIFLUOROACETONITRILE, Russian chemical bulletin, 44(7), 1995, pp. 1283-1285
Citations number
13
Categorie Soggetti
Chemistry
Journal title
Russian chemical bulletin → ACNP
ISSN journal
10665285
Volume
44
Issue
7
Year of publication
1995
Pages
1283 - 1285
Database
ISI
SICI code
1066-5285(1995)44:7<1283:CSOE>2.0.ZU;2-N
Abstract
Ethyl 2-acetyl-3-amino-4,4,4-trifluoro-2-butenoate was synthesized by treatment of ethyl acetoacetate with CF3CN in the presence of Ni(acac) (2). Condensation of the diphenylboron chelate of the former with dime thylformamide dimethylacetal followed by refluxing in ethanol yielded thoxycarbonyl-4-hydroxy-2-trifluoromethylpyridine.