1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL FOR THE REMOVAL OF THE 4,4'-DIMETHOXYTRITYL PROTECTING GROUP FROM THE 5'-HYDROXYL OF ACID-SENSITIVE NUCLEOSIDES AND NUCLEOTIDES

Authors
LEONARD NJ",NEELIMA
Citation
Leonard Nj",neelima, 1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL FOR THE REMOVAL OF THE 4,4'-DIMETHOXYTRITYL PROTECTING GROUP FROM THE 5'-HYDROXYL OF ACID-SENSITIVE NUCLEOSIDES AND NUCLEOTIDES, Tetrahedron letters, 36(43), 1995, pp. 7833-7836
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
43
Year of publication
1995
Pages
7833 - 7836
Database
ISI
SICI code
0040-4039(1995)36:43<7833:1FTROT>2.0.ZU;2-B
Abstract
1,1,1,3,3,3-Hexafluoro-2-propanol is introduced as a suitable reagent and solvent for the detritylation of 5'-O-(4,4'-dimethoxytrityl)-nucle osides and -deoxynucleosides, especially those that are susceptible to N-glycosyl cleavage under more strongly acidic conditions.