SYNTHESIS OF C-5'-SUBSTITUTED 2'-DEOXYNUC LEOSIDES

Authors
NACRO K ESCUDIER JM BALTAS M GORRICHON L
Citation
K. Nacro et al., SYNTHESIS OF C-5'-SUBSTITUTED 2'-DEOXYNUC LEOSIDES, Tetrahedron letters, 36(43), 1995, pp. 7867-7870
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
43
Year of publication
1995
Pages
7867 - 7870
Database
ISI
SICI code
0040-4039(1995)36:43<7867:SOC2L>2.0.ZU;2-3
Abstract
Stereocontrolled lactonisation of gamma,delta-epoxy beta-hydroxyesters provides, after reduction, 2-deoxysugars in pyrano or furano form. Af ter appropriate protections of the hydroxyl functions, these sugars ca n be converted to various 2'-deoxynucleosides with different configura tion of the sugar moiety and an extra functionalisation at C-5.