A NOVEL FAMILY OF GENES ENCODING PUTATIVE PHEROMONE RECEPTORS IN MAMMALS

In mammals, olfactory sensory perception is mediated by two anatomical ly and functionally distinct sensory organs: the main olfactory epithe lium (MOE) and the vomeronasal organ (VNO). Pheromones activate the VN O and elicit a characteristic array of innate reproductive and social behaviors, along with dramatic neuroendocrine responses. Differential screening of cDNA libraries constructed from single sensory neurons fr om the rat VNO has led to the isolation of a family of about 30 putati ve receptor genes. Sequence analysis indicates that these genes compri se a novel family of seven transmembrane domain proteins unrelated to the receptors expressed in the MOE. Moreover, the expression of each m ember of the gene family is restricted to a small subpopulation of VNO neurons. These genes are likely to encode mammalian pheromone recepto rs.