S. Koochekpour et al., VASCULAR ENDOTHELIAL GROWTH-FACTOR PRODUCTION IS STIMULATED IN RESPONSE TO GROWTH-FACTORS IN HUMAN GLIOMA-CELLS, Oncology Reports, 2(6), 1995, pp. 1059-1061
Neovascularization is essential for tumour growth and is mediated by p
hysiological substances produced by tumours. Vascular endothelial grow
th factor (VEGF) is one such potent angiogenic factor. Human gliomas,
the most important class of intrinsic brain tumours, express VEGF both
in vivo and in vitro. Factors involved in the control of VEGF product
ion by glioma cells are not well known. In this study, we investigated
the role of basic fibroblast growth factor (bFGF), epidermal growth f
actor (EGF), and platelet derived growth factors (PDGF) on VEGF produc
tion by four different glioma cell lines in vitro. With the exception
of PDGF A/A and B/B in one cell line, all growth factors differentiall
y stimulated VEGF production in all cell lines investigated. These dat
a suggest that VEGF production in human glioma may be regulated by oth
er growth factors which are also known to be expressed in such tumours
.