SYNTHESIS OF FK506-CYCLOSPORINE HYBRID MACROCYCLES

Authors
TEAGUE SJ COOPER ME STOCKS MJ
Citation
Sj. Teague et al., SYNTHESIS OF FK506-CYCLOSPORINE HYBRID MACROCYCLES, Bioorganic & medicinal chemistry letters, 5(20), 1995, pp. 2341-2346
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
20
Year of publication
1995
Pages
2341 - 2346
Database
ISI
SICI code
0960-894X(1995)5:20<2341:SOFHM>2.0.ZU;2-U
Abstract
An attempt was made to synthesise calcineurin inhibitors using dual do main macrocyclic compounds that incorporated a FKBP12 binding domain t ogether with a calcineurin recognition domain which had been designed by consideration of the relevant features of both FK506 and Cyclospori n A.