SILICON-MEDIATED INACTIVATION OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE

Authors
DANZIN C COLLARD JN MARCHAL P SCHIRLIN D
Citation
C. Danzin et al., SILICON-MEDIATED INACTIVATION OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE, Bioorganic & medicinal chemistry letters, 5(20), 1995, pp. 2363-2366
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
20
Year of publication
1995
Pages
2363 - 2366
Database
ISI
SICI code
0960-894X(1995)5:20<2363:SIOSAO>2.0.ZU;2-S
Abstract
Several organosilicon amines were synthesized as potential mechanism-b ased inhibitors of semi-carbazide-sensitive amine oxidase (SSAO) prepa red from rat aorta. 2-[Dimethyl(2-phenylethyl)silyl]-methanamine, hydr ochloride produced potent time-dependent inhibition of SSAO. A potenti al mechanism is proposed to explain SSAO inactivation by organosilicon amines.