SYNTHESIS OF CHROMOPHORIC DIPEPTIDES AS SUBSTRATES FOR PAPAIN

Authors
DORAN JD TONGE PJ CAREY PR ARYA P
Citation
Jd. Doran et al., SYNTHESIS OF CHROMOPHORIC DIPEPTIDES AS SUBSTRATES FOR PAPAIN, Bioorganic & medicinal chemistry letters, 5(20), 1995, pp. 2381-2384
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
20
Year of publication
1995
Pages
2381 - 2384
Database
ISI
SICI code
0960-894X(1995)5:20<2381:SOCDAS>2.0.ZU;2-E
Abstract
Chromophoric dipeptides (2) and (3) are found to be better substrates for papain in comparison to simpler substrates 1a or 1b. A synthetic s trategy for obtaining alpha-NH(COOEt)5-MTA-Et (1b), Ala-5-MTA-Et(2), P he-5-MTA-Et(3) has been described.