PHOTOINDUCED ELECTRON-TRANSFER FOR PYRENESULFONAMIDE CONJUGATES OF TRYPTOPHAN-CONTAINING PEPTIDES - MITIGATION OF FLUOROPROBE BEHAVIOR IN N-TERMINAL LABELING EXPERIMENTS

Authors
JONES G LU LN VULLEV V GOSZTOLA DJ GREENFIELD SR WASIELEWSKI MR
Citation
G. Jones et al., PHOTOINDUCED ELECTRON-TRANSFER FOR PYRENESULFONAMIDE CONJUGATES OF TRYPTOPHAN-CONTAINING PEPTIDES - MITIGATION OF FLUOROPROBE BEHAVIOR IN N-TERMINAL LABELING EXPERIMENTS, Bioorganic & medicinal chemistry letters, 5(20), 1995, pp. 2385-2390
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
20
Year of publication
1995
Pages
2385 - 2390
Database
ISI
SICI code
0960-894X(1995)5:20<2385:PEFPCO>2.0.ZU;2-E
Abstract
The (nitro)pyrenesulfonamide group has been attached to the N-terminus of tryptophan and tryptophan-containing peptides. Intramolecular elec tron transfer between pyrene and Trp indole side chains, observed by f luorescence quenching and laser flash photolysis, depends on the spaci ng between Pyr and Trp moieties and the strength of the electron accep tor.