ISOLATION, STRUCTURE DETERMINATION AND SQUALENE SYNTHASE ACTIVITY OF L-731,120 AND L-731,128, ALKYL CITRATE ANALOGS OF ZARAGOZIC-ACID-A ANDZARAGOZIC-ACID-B

Two new alkyl citrates, L-731,120 and L-731,128, with alkyl chains cor responding to those of zaragozic acids A and B, were isolated as minor components of large scale fungal fermentations producing zaragozic ac id A and B. They are submicromolar inhibitors of squalene synthase in vitro.