THE EFFECT OF N-ALKYLATION ON THE GAS-PHASE BASICITIES OF SMALL PEPTIDES MEASURED BY THE KINETIC METHOD

Gas phase basicities for a series of N-alkylated peptides were found b y the kinetic method using amines and guanidines as reference bases. T he basicity value of one of these peptides was then remeasured using t he rest of the derivatized peptides as reference bases. Both values ap pear to be in a good agreement. This suggests that structurally simila r peptides (with unaltered topology of intramolecular hydrogen bonding ) can be used as reference bases in the kinetic method experiments.