PURIFICATION FROM HUMAN PLASMA OF A TETRAPEPTIDE THAT POTENTIATES INSULIN-LIKE GROWTH-FACTOR-I ACTIVITY IN CHICK-EMBRYO CARTILAGE

Authors
STACZEK J MAACHI F LENGUYEN D BECCHI M HEULIN MH NABET P BELLEVILLE F
Citation
J. Staczek et al., PURIFICATION FROM HUMAN PLASMA OF A TETRAPEPTIDE THAT POTENTIATES INSULIN-LIKE GROWTH-FACTOR-I ACTIVITY IN CHICK-EMBRYO CARTILAGE, FEBS letters, 373(3), 1995, pp. 207-211
Citations number
37
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
373
Issue
3
Year of publication
1995
Pages
207 - 211
Database
ISI
SICI code
0014-5793(1995)373:3<207:PFHPOA>2.0.ZU;2-D
Abstract
Human plasma has been shown to contain a low molecular weight factor t hat potentiates human IGF-I stimulation of glycosaminoglycan synthesis in chick embryo cartilage. The peptide was purified and characterized by Edman degradation and electrospray mass spectrometry. The primary structure determined was: Trp-Gly-His-Glu. A homologous synthetic pept ide similarly promoted matrix biosynthesis in cartilage exposed to IGF -I.