DECREASED URINARY PEPTIDE EXCRETION IN SCHIZOPHRENIC-PATIENTS AFTER NEUROLEPTIC TREATMENT

Six schizophrenic patients had their urinary peptide, levels measured before and after 5 weeks of treatment with neuroleptic medications. Fo r two patients, levels were also measured after a reduction in the neu roleptic dose. Because of the heterogeneity of peptide peaks with the same bioactivity, the overall peptide levels were compared to initial levels. A neuroleptic effect on peptide levels was demonstrated. Sever al research groups have reported enzyme induction caused by neurolepti cs in vivo.