GROWTH MODIFYING PROPERTIES OF 2'-5'-OLIGONUCLEOTIDES OF ADENYLIC ACID

Authors
SENIUK OF STOGNIY AB TARASENKO PD ROMASHKO VV MATSUKA GK SKOROBOGATKO OV STEPANOVA EV
Citation
Of. Seniuk et al., GROWTH MODIFYING PROPERTIES OF 2'-5'-OLIGONUCLEOTIDES OF ADENYLIC ACID, Eksperimental'naa onkologia, 17(2), 1995, pp. 89-94
Citations number
12
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
17
Issue
2
Year of publication
1995
Pages
89 - 94
Database
ISI
SICI code
0204-3564(1995)17:2<89:GMPO2O>2.0.ZU;2-X
Abstract
It has been shown, that the 2'-5'-oligonucleotide of adenylic acid (de phosphorylated trinucleotide) possessed the interferon-like growth-mod ifying activity towards lymphocytes and tumor cells. The orientation a nd expression of such activity depends on both the nature and dose of the substance and functional state of the cells tested. This activity may have alternative directions such as stimulation and inhibition of the function tested.