Mechanoluminescence (ML) is optical integral emission over the range o
f 200-600 nm resulting from the mechanical activation of lymphocytes o
f spleen of C57BI/6 mice with Lewis' carcinoma in the result of ultras
onic emission influence as well as centrofugal acceleration on the men
tioned cells has some peculiarities as compared to analogous indices i
n the intact animals. We noted the fact of multidirectional fluctuatio
n in some sites of Mt spectrum of periferal blood lymphocytes (PBL) ov
er the range of 242-600 nm from patients with nonsmall lung cancer, ch
ronic pneumonia and practically healthy donors which is supposed to be
used as additional diagnostic test of oncologic and inflammatory path
ologies. In the experiments in vitro, it is shown the dependence of Mt
DNA intensity on its concentration and on dose of polyamine (spermidi
ne) incubated with it, and on the basis of that the possible interpret
ation of the role of endogenic Mt DNA in the immunologic reactions in
oncogenesis is offered.