CHANGES IN THE RECEPTOR STATUS OF RAT MAMMARY-TUMORS AFTER TAMOXIFEN ADMINISTRATION

Authors
BURLAKA DP GUTNIK NS SHERBAN SD VINNITSKY VB
Citation
Dp. Burlaka et al., CHANGES IN THE RECEPTOR STATUS OF RAT MAMMARY-TUMORS AFTER TAMOXIFEN ADMINISTRATION, Eksperimental'naa onkologia, 17(2), 1995, pp. 141-144
Citations number
19
Categorie Soggetti
Oncology
Journal title
Eksperimental'naa onkologia → ACNP
ISSN journal
02043564
Volume
17
Issue
2
Year of publication
1995
Pages
141 - 144
Database
ISI
SICI code
0204-3564(1995)17:2<141:CITRSO>2.0.ZU;2-R
Abstract
The influence of antiestrogen preparation tamoxifen on the growth of D MBA-induced mammary tumors in Sprague-Dawly rats and on the level of e stradiol and progesterone receptors in tumors was studied. Tamoxifen w as found to lead to a delay in tumor growth that is resumed after a ce rtain time. Continuous administration of tamoxifen reduces considerabl y the level of hormone receptors in DMBA-induced rat mammary tumors.