EFFECT OF MET-ENKEPHALIN AND OPIOID ANTAGONISTS ON RAT MACROPHAGES

Authors
RADULOVIC J DIMITRIJEVIC M LABAN O STANOJEVIC S VASILJEVIC T KOVACEVICJOVANOVIC V MARKOVIC BM
Citation
J. Radulovic et al., EFFECT OF MET-ENKEPHALIN AND OPIOID ANTAGONISTS ON RAT MACROPHAGES, Peptides, 16(7), 1995, pp. 1209-1213
Citations number
30
Categorie Soggetti
Biology
Journal title
Peptides → ACNP
ISSN journal
01969781
Volume
16
Issue
7
Year of publication
1995
Pages
1209 - 1213
Database
ISI
SICI code
0196-9781(1995)16:7<1209:EOMAOA>2.0.ZU;2-V
Abstract
Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 rel ease by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA a nd AO rats, respectively. These effects were antagonized by low, but n ot high, concentrations of naloxone and ICI 174864. High concentration s of both antagonists directly modulated H2O2 release and retained the strain-related differences seen with Met-ENK. The results showed dire ct, strain- and dose-dependent, effects of Met-ENK, naloxone, and ICI 174864 on rat macrophage function.