NUCLEOTIDE EXCISION-REPAIR AND THE LINK WITH TRANSCRIPTION

Authors
LEHMANN AR
Citation
Ar. Lehmann, NUCLEOTIDE EXCISION-REPAIR AND THE LINK WITH TRANSCRIPTION, Trends in biochemical sciences, 20(10), 1995, pp. 402-405
Citations number
29
Categorie Soggetti
Biology
Journal title
Trends in biochemical sciences → ACNP
ISSN journal
09680004
Volume
20
Issue
10
Year of publication
1995
Pages
402 - 405
Database
ISI
SICI code
0968-0004(1995)20:10<402:NEATLW>2.0.ZU;2-H
Abstract
Nucleotide excision repair (NER) uses the products of about 30 genes t o remove a damage-containing oligonucleotide from cellular DNA. The tr anscription factor TFIIH is an essential component of NER, in man, def ects in NER can result in three distinct genetic disorders, whose feat ures can be ascribed to abnormalities in DNA repair or transcription.