SUCCESSFUL ALLOGENEIC BONE-MARROW TRANSPLANTATION IN A CASE WITH MYELODYSPLASTIC SYNDROME WHICH DEVELOPED FOLLOWING FANCONI-ANEMIA

Authors
IKUSHIMA S HIBI S TODO S SAWADA T MATSUMOTO Y IWAMI H TSUNAMOTO K KASUBUCHI Y YABE M KATO S IMASHUKU S
Citation
S. Ikushima et al., SUCCESSFUL ALLOGENEIC BONE-MARROW TRANSPLANTATION IN A CASE WITH MYELODYSPLASTIC SYNDROME WHICH DEVELOPED FOLLOWING FANCONI-ANEMIA, Bone marrow transplantation, 16(4), 1995, pp. 621-624
Citations number
21
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
Bone marrow transplantation → ACNP
ISSN journal
02683369
Volume
16
Issue
4
Year of publication
1995
Pages
621 - 624
Database
ISI
SICI code
0268-3369(1995)16:4<621:SABTIA>2.0.ZU;2-4
Abstract
We report the case of a 14-year-old boy with myelo-dysplastic syndrome (MDS/RAEB) which developed following Fanconi anemia. The patient rece ived BMT from an HLA-identical sister. Based on the in vitro CY-sensit ivity test, 100 mg/kg of CY was administered for conditioning combined with 6 Gy TBI. Mucosal symptoms such as stomatitis, diarrhea and hema turia were severe, but manageable, and engraftment was successful. The patient has maintained normal trilineage hematopoiesis with >90% Karn ofsky score for 30 months with disappearance of a clonal chromosomal a bnormality (47,XY, +i(lq)) which was detected before BMT.