ANTIBIOTIC SUSCEPTIBILITY OF BACTEROIDES-FRAGILIS GROUP STRAINS IN HUNGARY

Resistance rates to different antibiotics of 495 Bacteroides fragilis group strains were followed between 1987 and 1994 in Hungary. In 1992 the strains were collected in three different laboratories, whereas du ring the other periods strains were isolated in one centre. Metronidaz ole, chloramphenicol, imipenem and amoxicillin/clavulanic acid were th e most active drugs. A high level of resistance was observed in 1987 f or ampicillin (88% at >4 mg/L), erythromycin (51% at >4 mg/L), tetracy clin (53% at >8 mg/L) and clindamycin (27% at >4 mg/L). The same level of resistance was seen during the further years for clindamycin and a mpicillin. Resistance to cefoxitin increased from 6% to 11% between 19 87 and 1993/1994. No differences in resistance rates were observed bet ween the strains collected in the three centers. For 100 strains, the results of the E test were compared with those of the micro-broth dilu tion test, both being used routinely for testing the antibiotic suscep tibility of Bacteroides fragilis group strains in this period. (C) 199 5 Academic Press