NORMALIZATION OF INSULIN-RESISTANCE IN NONOBESE ESSENTIAL-HYPERTENSION BY CILAZAPRIL TREATMENT

To determine whether ACE inhibitor other than captopril improves insul in sensitivity in patients with essential hypertension, we measured in sulin sensitivity to glucose utilization using SSPG method in 10 lean hypertensive subjects before and after chronic cilazapril treatment (1 .5+/-0.2 mg/day, 15.6+/-2.1 weeks). The results were Compared with tho se obtained in 10 healthy control subjects. SSPG obtained by insulin s ensitivity test was significantly higher in hypertensive subjects, ind icating a lower insulin sensitivity than in controls. After cilazapril treatment, SSPG reduced significantly to the level which was statisti cally not different from control subjects. Hyperinsulinemia diminished after treatment, while no significant change of blood glucose was obs erved during oral glucose tolerance test in hypertensive subjects. Pla sma HDL cholesterol increased by cilazapril treatment. Cilazapril trea tment has beneficial effect in the reversal of insulin resistance in p atients with essential hypertension.