Despite the potential of modern pharmacotherapy to control disease and
enhance quality of life, two out of five patients fail to take their
prescribed medication correctly. Research indicates that the two prima
ry influencers of adherence are the patient's beliefs in the value of
the regimen and the patient's ability to overcome practical barriers t
o adherence. The patient's perception of value-ie, the risks, benefits
, and efficacy of therapy-influences his or her commitment to the medi
cation regimen. Barriers to adherence include side effects, number and
frequency of dosages, and cost. Communication between health care pro
viders and patients is crucial to enhancing patient adherence to medic
ation regimens.