OUTCOME OF OVUM DONATION IN TURNERS-SYNDROME PATIENTS

Objective: To determine whether there is a difference in the pregnancy rate in women with Turner's syndrome (45,X) in an ovum donation progr am compared with women with other causes of premature ovarian failure. Design: Retrospective chart review of women with Turner's syndrome (n = 11) and premature ovarian failure (n = 38) in a donor ovum program using variable dose and duration of E(2) replacement therapy for endom etrial preparation and using only transvaginal ultrasonographic assess ment of endometrial response before ET. Results: The pregnancy rates i n Turner's syndrome patients and control subjects were 27% and 25%, re spectively. Pregnancy rates were higher in the first cycle than in sub sequent cycles for both groups (40% versus 8%). Conclusions: Turner's syndrome patients given a variable dose of estrogen, for endometrial p reparation, with response assessed exclusively by transvaginal ultraso nography demonstrated pregnancy rates equal to patients with other cau ses of premature ovarian failure.