Objective: To determine whether there is a difference in the pregnancy
rate in women with Turner's syndrome (45,X) in an ovum donation progr
am compared with women with other causes of premature ovarian failure.
Design: Retrospective chart review of women with Turner's syndrome (n
= 11) and premature ovarian failure (n = 38) in a donor ovum program
using variable dose and duration of E(2) replacement therapy for endom
etrial preparation and using only transvaginal ultrasonographic assess
ment of endometrial response before ET. Results: The pregnancy rates i
n Turner's syndrome patients and control subjects were 27% and 25%, re
spectively. Pregnancy rates were higher in the first cycle than in sub
sequent cycles for both groups (40% versus 8%). Conclusions: Turner's
syndrome patients given a variable dose of estrogen, for endometrial p
reparation, with response assessed exclusively by transvaginal ultraso
nography demonstrated pregnancy rates equal to patients with other cau
ses of premature ovarian failure.