The versatility of modular total hip arthroplasties have rapidly exten
ded their applications. However, these new interfaces can lead to comp
lications that were not observed with monolithic components. These pro
blems have been noted with modular femoral and acetabular components a
nd have been associated with the generation of particulate debris. Thi
s article reviews the authors' clinical observations and histologic, b
iomechanic, and spectophotometric evaluations of modular total hip art
hroplasties. New data comparing both synovial fluid metal levels in we
ll-fixed and loose monolithic and modular prosthetic hip implants are
presented. In modular total hip components synovial fluid cobalt level
s correlated positively with patient weight and length of implantation
. The generation of particulate debris in modular total hip components
may induce periprosthetic osteolysis. Taper locks for femoral compone
nts and locking mechanisms for the polyethylene liner and metallic cup
must be designed to avoid the production of particulate debris.