ENHANCED GABA-B RECEPTOR-MEDIATED TRANSMISSION IN ALCOHOL-DEPENDENCE SYNDROME

Authors
MACDONALD S CORRIGAN FM GASKELL DF FRENCH M
Citation
S. Macdonald et al., ENHANCED GABA-B RECEPTOR-MEDIATED TRANSMISSION IN ALCOHOL-DEPENDENCE SYNDROME, J PSYCHOPH, 10(4), 1996, pp. 321-323
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences,"Clinical Neurology
Journal title
JOURNAL OF PSYCHOPHARMACOLOGY
ISSN journal
02698811 → ACNP
Volume
10
Issue
4
Year of publication
1996
Pages
321 - 323
Database
ISI
SICI code
0269-8811(1996)10:4<321:EGRTIA>2.0.ZU;2-R
Abstract
We have studied the GABAb receptor-mediated neurotransmissions of alco holic patients by administering baclofen 10 mg orally and measuring th e growth hormone (GH) response. There was a minimal GH response to the baclofen in one of eight control subjects and a greater GH response i n 11 of the 16 alcoholic patients. There is thus evidence for increase d transmission at the GABAb receptor in detoxified patients with alcoh ol-dependence syndrome.