N. Plato et al., CANCER INCIDENCE, MORTALITY AND EXPOSURE-RESPONSE AMONG SWEDISH MAN-MADE VITREOUS FIBER PRODUCTION WORKERS, Scandinavian journal of work, environment & health, 21(5), 1995, pp. 353-361
Objective The objective of this study was to provide an extended follo
w-up of workers in three Swedish plants producing man-made vitreous fi
bers (MMVF). Method Mortality and cancer incidence was investigated am
ong 3539 male acid female workers, employed for at least one year befo
re 1978. Mortality was followed from 1952 to 1990 and cancer incidence
from 1958 to 1989. National and regional mortality and cancer inciden
ce rates were used to calculate the expected numbers. Results Twenty-s
even lung cancer deaths were observed compared with 23 expected (stand
ardized mortality ratio 117, 95% confidence interval 81-176), based on
regional mortality. With a latency time of 30 years, the lung cancer
risk was significantly elevated, but no trend was found for the standa
rdized mortality ratio with increasing duration of exposure to MMVF. T
he lung cancer and stomach cancer mortality was higher in the rock woo
l industry than in the fiber glass industry. Fiber exposure from 1938
to 1990 was estimated in the two rock wool plants by applying a model
for historical fiber exposure estimation, specific for different job t
itles in the rock wool production industry. No relationship was found
between individually cumulated rock wool fiber exposure and lung cance
r or stomach cancer risk. Conclusions The numbers of lung cancers and
stomach cancer cases were low and did not therefore allow more general
conclusions regarding the cancer hazard for exposed workers. A large
European study in progress will probably allow more precise conclusion
s.