Pc. Debruin et al., CD30 EXPRESSION IN NORMAL AND NEOPLASTIC LYMPHOID-TISSUE - BIOLOGICALASPECTS AND CLINICAL IMPLICATIONS, Leukemia, 9(10), 1995, pp. 1620-1627
CD30 expression is found on Hodgkin and Reed-Sternberg cells, anaplast
ic large cell lymphoma cells and on activated B or T lymphocytes. Rece
ntly CD30 was shown to be a transmembrane receptor that is significant
ly homologous to the tumor necrosis factor receptor (TNFR) family. Lig
ands for most members of this family, including CD30, have now been id
entified. This review summarizes the role of the different TNFR family
members in lymphocyte proliferation and differentiation in an attempt
to understand more clearly the role of CD30 expression in the pathoge
nesis and clinical behavior of non-Hodgkin's lymphomas. We state that
CD30 expression is of prognostic relevance in primary cutaneous and no
dal T cell lymphomas in contrast to the absence of clinical relevance
of CD30 expression in B cell lymphomas.