DEVELOPMENT OF NOVEL SYNTHETIC METHOD FOR POLYFUNCTIONALIZED HETEROCYCLES

Polyfunctionalized heterocycles have been important key compounds in t he fields of functional and biologically active substances. From this point of view, we have developed novel synthetic methods for polyfunct ional ized heterocycles according to the following approaches, 1) pola r cycloadditions of three-membered heterocycles and azadienes. 2) func tionalization of pyridine nucleus leading to condensed pyridine deriva tives, 3) molecular design of novel electron transfer catalysts based on chemical simulation of coenzyme PQQ and TTQ, 4) application of hete roatom compounds as heterocyclic building blocks.