PEROXYNITRITE CAUSES APOPTOSIS IN RAT THYMOCYTES

Authors
SALGO MG SQUADRITO GL PRYOR WA
Citation
Mg. Salgo et al., PEROXYNITRITE CAUSES APOPTOSIS IN RAT THYMOCYTES, Biochemical and biophysical research communications, 215(3), 1995, pp. 1111-1118
Citations number
36
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
215
Issue
3
Year of publication
1995
Pages
1111 - 1118
Database
ISI
SICI code
0006-291X(1995)215:3<1111:PCAIRT>2.0.ZU;2-W
Abstract
Peroxynitrite is demonstrated to cause apoptosis in freshly harvested rat thymocytes suspended in phosphate buffer, as shown by the typical ladder pattern of DNA fragmentation. This evidence suggests a new func tion for peroxynitrite, already known to be a strong oxidant. Peroxyni trite can nick DNA, oxidize cellular thiols and initiate the apoptotic process responsible for genomic degradation. (C) 1995 Academic Press, Inc.