A DELIVERY SYSTEM FOR THE CONCURRENT ADMINISTRATION OF HYDROCHLOROTHIAZIDE AND CAPTOPRIL

A delivery system for the concurrent administration of drugs was prepa red inserting a conventional hydrochlorothiazide tablet in the hole of a perforated matrix of captopril coated on all the surfaces except th e hole surface. The influence of both the hole diameter and the drug/p olymer ratio on the release process was evaluated. According to the sy stem design, hydrochlorothiazide was promptly liberated from the table t inserted in the hole, whereas captopril was gradually released follo wing a linear release profile. No significant differences were pointed out between the release behavior of both drugs in de-ionized water an d in simulated gastrointestinal fluids.