ABNORMAL CHROMATIN CLUMPING IN GRANULOCYTES IN A CASE OF PH1-NEGATIVE, BCR-ABL REARRANGEMENT POSITIVE, HEMATOLOGICALLY ATYPICAL CHRONIC MYELOID-LEUKEMIA (CML)

In the present study, we report the case of a patient displaying an ab normal chromatin clumping (ACC) syndrome, a rare disease which shares features with both myeloproliferative and myelodysplastic disorders. A lthough various non specific cytogenetic abnormalities have been obser ved in ACC, the presence of a Ph1 chromosome has not been reported. In our patient, despite a lack of Ph1, PCR analysis of blood and bone ma rrow samples revealed a BCR-ABL rearrangement. These results indicate that at least some cases of ACC syndrome could represent a form of Ph1 -negative chronic myeloid leukaemia.